Theme 2 – Re‑irradiation

Theme 2 aims to transform the use of re-irradiation. We will develop re-irradiation strategies tailored to the individual patient, incorporating radiobiology, anatomical changes, and multi-modality imaging, and take these strategies into the clinic in pilot studies in rectal and prostate cancer.

Theme Leads

Work Package 3 – Re‑irradiation – Combining imaging with radiobiology

Work package 3 will create methodology, technical solutions and data analysis strategies for re-irradiation. We will combine prior dose distribution, state-of-the-art deformable image registration, and radiobiology, as well as pre-treatment functional imaging to identify sub-clinical damage from previous radiotherapy, to guide safe re-irradiation and assess toxicity following treatment.

Work Package 4 – Taking novel re-irradiation into the clinic

Work package 4 will take the solutions from WP3 into the clinic, as pilot studies in rectal and prostate cancer. These studies will focus on neo-adjuvant re-irradiation in recurrent rectal cancer, primary prostate re-irradiation in localised castrate resistant locally recurrent prostate cancer, and pelvic SABR and elective nodal irradiation for pelvic oligometastatic disease.

Other WP4 Researchers